IKK alpha/beta Recombinant Rabbit mAb (S-1317-27),Starter_specification/price/image

Product Detail
Company Profile

Product Specification

Host	Rabbit
Antigen	IKK alpha/beta
Synonyms	Inhibitor of nuclear factor kappa-B kinase subunit alpha, I-kappa-B kinase alpha, IKK-A, IkBKA, IkappaB kinase, Conserved helix-loop-helix ubiquitous kinase, I-kappa-B kinase 1, Nuclear factor NF-kappa-B inhibitor kinase alpha (NFKBIKA), Transcription factor 16 (TCF-16), CHUK, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B-kinase beta, IKK-B, IkBKB, I-kappa-B kinase 2, Nuclear factor NF-kappa-B inhibitor kinase beta (NFKBIKB), Serine/threonine protein kinase IKBKB, IKBKB
Immunogen	Recombinant Protein
Location	Cytoplasm, Nucleus
Accession	O14920、 O15111
Clone Number	S-1317-27
Antibody Type	Recombinant mAb
Isotype	IgG
Application	WB, ICC, ICFCM, IP
Reactivity	Hu, Ms, Rt
Purification	Protein A
Concentration	0.5 mg/ml
Conjugation	Unconjugated
Physical Appearance	Liquid
Storage Buffer	PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage	12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution

application	dilution	species
WB	1:1000	null
IP	1:50	null
ICC	1:50	null
ICFCM	1:50	null

Background

The Inhibitor of Nuclear Factor Kappa-B Kinase (IKK) is a pivotal serine/threonine kinase complex that plays a crucial role in regulating the Nuclear Factor Kappa-B (NF-κB) signaling pathway. This pathway is fundamental for controlling diverse physiological and pathological processes, including immune responses, inflammation, cell proliferation, and apoptosis. The IKK complex comprises three main subunits: IKKα (also known as IKK1), IKKβ (IKK2), and IKKγ (or NEMO/IKBKG). Each subunit contributes uniquely to the complex's structure and function. IKKα possesses kinase activity, albeit lower than IKKβ. Its precise role in NF-κB activation remains somewhat elusive, but it may be involved in specific types of NF-κB activation. IKKβ serves as the primary kinase subunit within the complex, exhibiting robust kinase activity. IKKβ is essential for activating the NF-κB pathway by phosphorylating the inhibitory protein IκB, leading to its degradation and subsequent release of NF-κB for nuclear translocation and transcriptional activation. IKK's primary function lies in the activation of the NF-κB signaling pathway. By phosphorylating specific serine residues on the IκB proteins, IKK triggers their ubiquitination and subsequent degradation by the proteasome. This process frees NF-κB from inhibition, allowing it to translocate to the nucleus and activate the transcription of target genes.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.