Home >Products> Reagents >Antibody> FITC Mouse Anti-Human CD161 Antibody (S-R581)
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FITC Mouse Anti-Human CD161 Antibody (S-R581)
FITC Mouse Anti-Human CD161 Antibody (S-R581)
Place of Origin:
Singapore
Brand:
Starter
Model:
S0B5090-20T
Price:
100
Hits:
Updated:
8/25/2025
  • Product Detail
  • Company Profile

    Product Specification


    HostMouse
    AntigenCD161
    SynonymsKiller cell lectin-like receptor subfamily B member 1; C-type lectin domain family 5 member B; HNKR-P1a (NKR-P1A); Natural killer cell surface protein P1A; CLEC5B; NKRP1A; KLRB1
    LocationMembrane
    AccessionQ12918
    Clone NumberS-R581
    Antibody TypeMouse mAb
    IsotypeIgG1,k
    ApplicationFCM
    ReactivityHu
    Positive Samplehuman PBMC
    PurificationProtein G
    Concentration0.2 mg/ml
    ConjugationFITC
    Physical AppearanceLiquid
    Storage Buffer

    PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300

    Stability & Storage12 months from date of receipt / reconstitution, 2 to 8 掳C as supplied.

    Dilution


    applicationdilutionspecies
    FCM5渭l per million cells in 100渭l volumeHu

    Background

    CD161, also known as KLRB1 or NKRP1A, is a C-type lectin-like receptor primarily expressed on the surface of natural killer (NK) cells and a subset of T cells, including mucosal-associated invariant T (MAIT) cells and some CD8+ T cells. It is particularly enriched in immune cells located in mucosal sites such as the gut and liver. CD161 binds to its ligand, lectin-like transcript 1 (LLT1, also known as CLEC2D), and this interaction can have both inhibitory and costimulatory effects on immune cells. In the context of cancer immunotherapy, CD161 has been identified as a potential inhibitory receptor in glioma-infiltrating T cells. Its activation by CLEC2D on tumor or immunosuppressive cells can dampen T cell responses against cancer cells. Recent studies suggest that blocking the CD161-CLEC2D interaction may enhance T cell-mediated antitumor activity, making CD161 a promising target for cancer immunotherapy.

    bio-equip.cn
    AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
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