FOXA2 is member of a large family of nuclear transcription factors, termed the winged helix family of transcription factors, that are involved in cell commitment, differentiation, and gene transcription in a variety of organs, such as the central nervous system and derivatives of the foregut endoderm, including the gastrointestinal tract, lung, and liver. FOXA2 is required for the formation of foregut endoderm, from which the lung bud is derived, and plays a critical role in organogenesis of the lung.
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