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- SamuxMP a mass photometer for AAV analytics
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The Refeyn SamuxMP is a mass photometer optimised for adeno-associated virus (AAV) characterisation and is an essential analytical tool for laboratories working with AAVs. The SamuxMP precisely measures the empty/full capsid ratio for AAVs of any serotype. SamuxMP mass photometry measurements are rapid and require very little sample.
Figure 1 Mass photometry measurement of AAV capsids (AAVDJ serotype) with SamuxMP. Two distinct peaks are visible: one with lower mass corresponding to empty capsids, and a second with higher mass corresponding to full capsids.
Empty/full measurement of AAVs
Mass photometry is a bioanalytical technology that measures the mass of individual AAV particles in solution, rapidly and using small sample amounts.
Mass photometry is ideally suited for measurements of empty/full capsid ratios, as filled AAV capsids have greater mass, so they can be distinguished from empty capsids on mass photometry histograms (Fig 1).
Figure 2 Mass photometry measurements of empty AAV capsids of different serotypes on the SamuxMP. Mass histograms for four different AAV serotypes, with the mass and standard deviation calculated from three technical replicates.
Serotype-agnostic AAV analytics
Different AAV serotypes can be measured on the SamuxMP mass photometer.
Figure 2 shows SamuxMP measurements of empty AAV capsids of four different AAV serotypes.
For each sample, the mass photometry measurements with the SamuxMP revealed a single, symmetric peak at the expected mass, confirming that the SamuxMP produces consistent results across serotypes
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Refeyn Ltd. specialises in the development, production, and distribution of mass photometry technology for industry and academia. Mass photometry is a unique bioanalytical technology pioneered by Refeyn that enables the measurement of molecular mass at the single-particle level by quantifying light scattering from biomolecules in solution. Spun out of Oxford University in 2018, the company aims to make mass photometry accessible to all in the scientific community, enabling users to achieve new and better outcomes. Refeyn has been recognised for its unique approach to biomolecular analysis through multiple awards, including the Royal Society of Chemistry Emerging Technologies Competition. Applications of mass photometry include: sample characterisation and analysis of protein oligomerisation, biomolecular interactions, and macromolecular assemblies. Utilising the novel technology of mass photometry, Refeyn’s products are capable of accurate mass measurement of single molecules in solution, in their native state, and without the need for labels, opening up new possibilities for bioanalytic and research into biomolecular function.
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