| Cell Line Description |
5637 is a cell line that exhibits epithelial morphology and was isolated from the bladder of a 68-year-old Caucasian male patient with grade II carcinoma. The karyotype of 5637 cells has a modal chromosome number of 67, ranging from 59 to 71. 5637 cells produce and secrete multiple growth factors such as SCF, IL-1, IL-6, G-CSF, and GM-CSF. 5637 cells are tumorigenic and have been shown to induce tumors in nude mice inoculated subcutaneously. Oncogene-wise, 5637 cells are positive for FGFR3, PIK3CA, HRAS, KRAS, NRAS, TERT, and CDKN2A, but negative for TP53, belonging to the molecular bladder cancer subtype luminal. 5637 cells are a valuable tool in cancer research, especially in the study of growth factors, cell division, oncogenes, and bladder cancer. |
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