| Cell Line Description |
Caov-3 is a cell line with epithelial morphology that was isolated in 1976 from the ovaries of a 54-year-old Caucasian female patient with ovarian cancer. These cells form tightly packed colonies in adherent culture. All-trans retinoic acid has been shown to inhibit the in vitro growth of Caov-3 ovarian cancer cells. These cells express NB/70K, CA-125, Ba-2, and Ca-1 tumor-associated antigens. Caov-3 cells contain nonsense mutations in the p53 gene and have multiple copies of the ovarian cancer oncogene PIK3CA. They are sensitive to vinblastine, cisplatin, and doxorubicin. Although these cells will not grow in soft agar, they exhibit tumorigenic properties when injected into immunocompromised mice. Therefore, Caov-3 cells are particularly suitable for 3D cell culture experiments. |
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