SPG20 encodes a protein that contains a MIT (Microtubule Interacting and Trafficking molecule) domain. This protein may be involved in endosomal trafficking, microtubule dynamics, or both functions. Frameshift mutations associated with SPG20 cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). Troyer syndrome (SPG20) is a complicated type of hereditary spastic paraplegias (HSPs). HSP is a category of neurological disorder characterized by spasticity and muscle weakness in the lower limbs.
Mouse Spartin (SPG20) ELISA Kit employs a two-site sandwich ELISA to quantitate SPG20 in samples. An antibody specific for SPG20 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anySPG20 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for SPG20 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of SPG20 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Mouse Spartin (SPG20) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Find more details at http://www.abbkine.com/product/mouse-spartin-spg20-elisa-kit-kte70386/
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