Glutamate [NMDA] receptor subunit zeta-1 is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. The gene consists of 21 exons and is alternatively spliced, producing transcript variants differing in the C-terminus. Although the sequence of exon 5 is identical in human and rat, the alternative exon 5 splicing in rat has yet to be demonstrated in human. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits.

Human N-methyl-D-aspartic Acid IgG Antibody (NMDA-Ab-IgG) ELISA Kit has been pre-coated with an antibody specific to NMDA-Ab-IgG. Standards or samples are then added to the appropriate microtiter plate wells with a Horseradish Peroxidase (HRP)-conjugated NMDA-Ab-IgG and incubated. The competitive inhibition reaction is launched between with HRP labeled NMDA-Ab-IgG and unlabeled NMDA-Ab-IgG with the antibody. A substrate solution is added to the wells and the color develops in opposite to the amount of NMDA-Ab-IgG in the sample. The color development is stopped and the intensity of the color is measured.

Human N-methyl-D-aspartic Acid IgG Antibody (NMDA-Ab-IgG) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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