TM2D2 contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. This gene has multiple alternatively spliced transcript variants which encode two different isoforms.The deduced 214-amino acid protein contains several features of a G protein-coupled receptor, including 2 putative transmembrane domains in its C-terminal half, a DRY motif, and conserved cysteines and lysines. Northern blot analysis detected variable expression of a 1.35-kb BLP1 transcript in all human tissues examined.
Bovine TM2 domain-containing protein 2 (TM2D2) ELISA Kit employs a two-site sandwich ELISA to quantitate TM2D2 in samples. An antibody specific for TM2D2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyTM2D2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for TM2D2 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of TM2D2 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Bovine TM2 domain-containing protein 2 (TM2D2) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
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