Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by HDAC1 (histone deacetylase 1) belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
The Abbkine HDAC1 Mouse Mouse Monoclonal Antibody (4E1) was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen anddetects endogenous levels of HDAC1. The antibody has been validaed in IHC-P, IF and reacts with Human, Mouse, Rat samples.
Abbkine supplies below price/size: $100/30μl, $220/100μl, $360/200μl of Mouse Anti-HDAC1 Mouse Monoclonal Antibody (4E1) at https://www.abbkine.com/product/hdac1-mouse-monoclonal-antibody-4e1-abm40270.
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