Single domain antibody (also called domain antibody or sdAb) is an antibody fragment consisting of a single monomeric variable antibody domain andlacking the light chain and CH1 domain of the heavy chain. Like a whole antibody, it is able to bind selectively to a specific antigen. With a molecular weight of only 12–15 kDa, single domain antibodies are much smaller than common antibodies (150–160 kDa), and even smaller than Fab fragments (~50 kDa, one light chain and half a heavy chain) and single-chain variable fragments (~25 kDa). www.creative-biolabs.com/Nanobody-Single-Domain-Antibody.html
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Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. Our service portfolio includes mouse and rat monoclonal antibody production using hybridoma technology, human, monkey, rabbit,chicken, dog, llama and camel monoclonal antibody production using various antibody library technologies [including phage display, bacterial display and yeast display]. We are also professional in conducting in depth antibody humanization and affinity maturation usingphage display and DNA mutagenesis approaches. In addition, OEM services for bulk scale antibody manufacturing, including bacterial production of scFv, diabody, tandem scFv, miniantibody and Fab, and mammalian cell expression of minibody, chimeric IgG and IgG, are also available at the most competitive price in the industry.
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