1, About TripleTOF 5600+ System (MS)

1) Powerful high resolution, accurate mass spec systems for screening, quantitation, and unknown exploration.

2) Integrating comprehensive qualitative exploration, rapid profiling, and high-resolution quantitation workflows on a single platform providing fast and accurate answers for advanced workflows.

3) High-resolution, accurate mass spec solutions for combined qualitative and quantitative analysis for advanced workflows in academia and biopharma.

4) For routine food, environment, and forensic testing applications, as well as standard biologics characterization workflows; check out the X-Series QTOF systems.

5) The SCIEX TripleTOF 5600+ System extends the power of high-resolution quantitative and qualitative LC-MS/MS.

2, Features

1> For research use only. Not for use in diagnostic procedures.

The TripleTOF 5600+ System is an innovation in LC-MS/MS performance that uniquely integrates comprehensive,qualitative exploration, rapid profiling, and high-resolutionquantitation workflows on a single platform. It combines high-sensitivity detection, high resolution with the fast acquisition speeds, and stable mass accuracy over days of acquisition.

Expanding upon the capabilities of TripleTOF Technology, the 5600+ System provides broader applicability in pharmaceutical development and a new paradigm in proteomics research.

Featuring:

1) MS/MSALL with SWATH™ Acquisition – enabling comprehensive MS/MS quantitation in proteomics

2) Tools for 21 CFR 11 Compliance – in Analyst® TF 1.6 and MultiQuant™ Software, bringing the power of accurate mass to regulated bioanalysis

3) Optional SelexION™ Technology – for an additional dimension of separation

4) High resolution at unparalleled speed with 10 msec accumulation time

5) EasyMass™ Accuracy – without constant recalibration, over 50 hours of continuous LC-MS operation provides stable mass accuracy.

6) SmartSpeed™ 100Hz Acquisition – delivering high resolution for high-speed chromatography with up to 100 spectra in a second – even in Information-Dependent Acquisition (IDA) mode

7) Sensitive, high-resolution system – low limits of quantitation (LOQ) for a high-resolution system and equivalent to high-performance triple quadrupoles

The TripleTOF 5600+ System is the next generation in quadrupole TOF technology. Combining the best-in-class front end of the Triple Quad 5500 System with the Accelerator TOF Analyzer, this instrument adds high resolution at the speed and sensitivity needed to give %CVs and limits of quantitation (LOQ) equivalent to those of high-end triple quadrupoles.

Now for the first time, pharmaceutical, academic, and analytical testing scientists can integrate comprehensive,qualitative exploration, rapid profiling, and high-resolution quantitation of low-abundance analytes in very complex matrices – all on a single platform.

2> MS/MSALL with SWATH Acquisition

Quantitative MS/MS data that rivals triple quadrupole sensitivity and precision for every component in complex samples.  And... a complete digital archive of all precursor and product ions in a sample, for unlimited retrospective interrogation without the need to re-acquire data.

3> 21 CFR 11 Compliance Module

Software tools that support digital record-keeping and electronic signatures, enabling the use of TripleTOF Technology in a regulated environment.

4> Highest sensitivity with QJet Ion Guide and Accelerator TOF Analyzer

Low-abundance analytes easily discovered, identified, and quantified

5> SmartSpeed 100Hz Acquisition

The fastest, high-resolution system that generates more high-quality information from every sample, even when using fast chromatography

6> EasyMass Accuracy

Achieves high mass-accuracy without continuous recalibration, making it the easiest-to-use system for routine accurate mass.

7> One-touch productivity software

Increases productivity by facilitating powerful workflows to create information out of data

8>High resolution at up to 100 spectra per second

Definitive identification at high speed even when using fast chromatography

9> Magnetic levitation (MagLev) turbo pumps

Magnetic levitation (MagLev) turbo pumps

10> Explore Workflow

Explore complex samples in greater depth: Select up to 50 precursors per second – and generate high resolution and high mass-accuracy MS/MS data using powerful IDA (Information-Dependent Acquisition) algorithms and high-resolution, accurate-mass MS and MS/MS.

11> Profile Workflow

Profile samples for quant and qual in a single run: Quantify virtually every compound in the sample with high-resolution MS quantification and fast chromatography; confirm compound identity with high-resolution, accurate-mass MS/MS; and then mine the data for the information you need.

12> Quantify Workflow

Quantify analytes with high-resolution MRM transitions for highest specificity and confidence: Obtain high resolution at high and low masses in the same spectrum for high-resolution, MRM-like quantification. The LOQ's and dynamic range are equivalent to high-performance triple quadrupoles. Cycle times are as low as 10 msec and generate superior peak definition, even with fast LC separations. Quantification requires little optimization, and you can choose multiple fragments per precursor from the acquired full-scan MS/MS data.