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Stichodactyla toxin
Place of Origin:
France
Brand:
Smartox
Model:
0.1 mg
Supplier:
Smartox Biotech
Price:
120 €
Hits:
1288 
Updated:
6/18/2014
  • Product Detail
  • Company Profile
    ShK - Stichodactyla toxin, Kv1.3 blocker ShK (Stichodactyla helianthus Neurotoxin) has been isolated from the venom of the Carribean sea anemone Stoichactis helianthus. ShK inhibits voltage-dependent potassium channels. It blocks Kv1.3 (KCNA3) potently and also Kv1.1 (KCNA1), Kv1.4 (KCNA4) and Kv1.6 (KCNA6) respectively with a Kd of 11 pM, 16 pM, 312 pM and 165 pM. Interestingly, it was also demonstrated that ShK potently inhibits the hKv3.2b channel with an IC50 value of approximately 0.6 nM. Shk technical information AA sequence: Arg-Ser-Cys3-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys12-Thr-Ala-Phe-Gln-Cys17-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys28-Arg-Lys-Thr-Cys32-Gly-Thr-Cys35-OH Disulfide bonds: Cys3-Cys35, Cys12-Cys28 and Cys17-Cys32 Length (aa): 35 Formula: C169H274N54O48S7 Molecular Weight: 4054.85 Da Appearance: White lyophilized solid Solubility: water and saline buffer CAS number: 165168-50-3 Source: Synthetic Purity rate: > 97% http://www.smartox-biotech.com/en/potassium-channel/147-shk
    bio-equip.cn
    Smartox Biotechnology is specialized in supplying the life science research community with biological materials issued from animal's venoms. The company offers venom peptides for basic research and drug discovery solutions based on its venom collection and expertise.
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