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Margatoxin
Place of Origin:
France
Brand:
Smartox
Model:
0.1 mg
Supplier:
Smartox Biotech
Price:
135 €
Hits:
1176 
Updated:
6/18/2014
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  • Product Detail
  • Company Profile
    Margatoxin, Kv1.3 selective blocker Margatoxin (MgTx) is a component of the venom of Scorpio Centruroides margaritatus. Margatoxin preferentially inhibits voltage-dependent potassium channels Kv1.3 with an IC50 value around 50 pM (20 fold more potent than Charybdotoxin) and irreversibly inhibits the proliferation response of human T-cells at 20 µM concentration. Margatoxin is known to be less potent on Kv1.3 expressed in Xenopus Oocytes (IC50 around 1 nM). Margatoxin was also described to be a potent inhibitor of human vascular smooth muscle cell migration with an IC50 of 85 pM. Margatoxin technical information AA sequence: Thr-Ile-Ile-Asn-Val-Lys-Cys7-Thr-Ser-Pro-Lys-Gln-Cys13-Leu-Pro-Pro-Cys17-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys29-Met-Asn-Gly-Lys-Cys34-Lys-Cys36-Tyr-Pro-His-OH (Disulfide bonds between Cys7-Cys29, Cys13-Cys34 and Cys17-Cys36) Length (aa): 39 Formula: C178H286N52O50S7 Molecular Weight: 4179.03 Da Appearance: White lyophilized solid Solubility: water and saline buffer CAS number: [145808-47-5] Source: Synthetic Purity rate: > 97 % http://www.smartox-biotech.com/en/potassium-channel/141-margatoxin
    bio-equip.cn
    Smartox Biotechnology is specialized in supplying the life science research community with biological materials issued from animal's venoms. The company offers venom peptides for basic research and drug discovery solutions based on its venom collection and expertise.
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