Login    Join free Add to favorites    中文
Home >Products> Physiology | Pharmacology | Neurology >Electrophysiology> Jingzhaotoxin III
Physiology | Pharmacology | Neurology:  Electrophysiology   Microtome   Animal Experimental Equipment   Animal Cages  
Jingzhaotoxin III
Place of Origin:
France
Brand:
Smartox
Model:
0.1 mg
Supplier:
Smartox Biotech
Price:
200 €
Hits:
1312 
Updated:
6/18/2014
Related Products | Other Products | Related Suppliers
  • Product Detail
  • Company Profile
    Jingzhaotoxin III, Selective blocker of Nav1.5 channel Jingzhaotoxin-III (ß-TRTX-Cj1α) has been isolated initially from the Chinese Tarantula spider Chilobrachys Jingzhao venom. Jingzhaotoxin-III selectively inhibits the activation of the voltage-dependent sodium channel Nav1.5 with an IC50 value close to 350 nM. It is inactive on Nav1.2, Nav1.4, Nav1.6 and Nav1.7 and should therefore be considered as an interesting research tool to discriminate between sodium channel subtypes. Jingzhaotoxin-III binds onto receptor site 4 presumably located on DIIS3-S4 linker of Nav1.5 and supposedly blocks Nav1.5 through a different mechanism than ProTx-II and Huwentoxin IV. ß-TRTX-Cj1α is composed of 36 amino acid residues including 6 cysteines cross-linked according to a C1-C4, C2-C5 and C3-C6 pattern. Jingzhaotoxin-III also inhibits Kv2.1 channel with an IC50 of around 700 nM. Jingzhaotoxin-III technical information AA sequence: Asp-Gly-Glu-Cys4-Gly-Gly-Phe-Trp-Trp-Lys-Cys11-Gly-Arg-Gly-Lys-Pro-Pro-Cys18-Cys19-Lys-Gly-Tyr-Ala-Cys24-Ser-Lys-Thr-Trp-Gly-Trp-Cys31-Ala-Val-Glu-Ala-Pro-OH Disulfide bonds: Cys4-Cys19, Cys11-Cys24, and Cys18-Cys31 Length (aa): 36 Formula: C174H241N47O46S6 Molecular Weight: 3919.53 Da Appearance: White lyophilized solid Solubility: aqueous buffer CAS number: not available Source: Synthetic Purity rate:> 98% http://www.smartox-biotech.com/en/sodium-channel/250-jingzhaotoxin-3
    bio-equip.cn
    Smartox Biotechnology is specialized in supplying the life science research community with biological materials issued from animal's venoms. The company offers venom peptides for basic research and drug discovery solutions based on its venom collection and expertise.
Request Information
Request Information: yes no
Request Quotation: yes no
refresh

I agree to share my inquiry with the other matching suppliers.

Send Now
Request Information

* Name:
Job Title:
* Tel:
Fax:
* E-mail:
Postcode:
Institution/Company:
Address:
* Country:
Request Information:
 yes no
Request Quotation:
 yes no
* Message:
* Verification Code:
 refresh
I agree to share my inquiry to the other matching suppliers.


Other Products

SiteMap
Copyright(C) 2006-2025 Bio-Equip E-mail:web@bio-equip.cn Tel:+86-17717806891 (Wechat)