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Chlorotoxin
Place of Origin:
France
Brand:
Smartox
Model:
0.1 mg
Supplier:
Smartox Biotech
Price:
140
Hits:
1730 
Updated:
6/18/2014
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  • Product Detail
  • Company Profile
    Chlorotoxin, Selective ligand of Glioma cells Chlorotoxin (Cltx) is a neurotoxin that was originally isolated from the venom of Leiurus quinquestriatus. Chlorotoxin is a specific ligand of glioma cells. Chlorotoxin binds to Cl- channels (small conductance epithelial chloride channels) in the brain and spinal cord and inhibits Cl- influx. Chlorotoxin most probably acts as a specific blocker, although residues both inside and outside of the pore region of the Cl- channels participate in chlorotoxin binding. It was demonstrated that chlorotoxin inhibits specifically the activity of matrix metalloproteinase-2 (MMP-2) without affecting MMP-1, MMP-3 and MMP-9. MMP-2 are upregulated in glioma cells and related cells making chlorotoxin a promising antitumoral drug and diagnosis tool. Chlorotoxin technical information AA sequence: Met-Cys2-Met-Pro-Cys5-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys16-Asp-Asp-Cys19-Cys20-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys28-Tyr-Gly-Pro-Gln-Cys33-Leu-Cys35-Arg-NH2 Disulfide bonds: Cys2-Cys19, Cys5-Cys28, Cys16-Cys33 and Cys20-Cys35 Length (aa): 36 Formula: C158H249N53O47S11 Molecular Weight: 3995.8 Da Appearance: White lyophilized solid Solubility: water and saline buffer CAS number: [163515-35-3] Source: Synthetic Purity rate: > 95 % http://www.smartox-biotech.com/en/chloride-channel/151-chlorotoxin
    bio-equip.cn
    Smartox Biotechnology is specialized in supplying the life science research community with biological materials issued from animal's venoms. The company offers venom peptides for basic research and drug discovery solutions based on its venom collection and expertise.
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