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Charybdotoxin
Place of Origin:
France
Brand:
Smartox
Model:
0.1 mg
Supplier:
Smartox Biotech
Price:
135 €
Hits:
1732 
Updated:
6/18/2014
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  • Product Detail
  • Company Profile
    Charybdotoxin - ChTx, KCa2+ channel blocker Charybdotoxin (ChTx) is a 37 amino acid peptide isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus that blocks voltage-gated and large conductance Ca2+ activated K+ channels KCa1.1 in nanomolar concentrations (IC50~ 3 nM). This blockade causes hyperexcitability of the nervous system. The toxin reversibly blocks channel activity by interacting at the external pore of the channel protein with an apparent Kd of 2.1 nM. ChTX also blocks KCa3.1 (IC50 5 nM), Kv1.2 (IC50 14 nM), Kv1.3 (IC50 2.6 nM) and Kv1.6 (IC50 2 nM) channels. Product specifications AA sequence: H-Pyr-Phe-Thr-Asn-Val-Ser-Cys7-Thr-Thr-Ser-Lys-Glu-Cys13-Trp-Ser-Val-Cys17-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys28-Met-Asn-Lys-Lys-Cys33-Arg-Cys35-Tyr-Ser-OH (Disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35) Length (aa): 37 Formula: C176H277N57O55S7 Molecular Weight: 4295.90 Da Appearance: White lyophilized solid Solubility: water and saline buffer CAS number: 95751-30-7 Source: Synthetic Purity rate: > 97% http://www.smartox-biotech.com/en/potassium-channel/202-charybdotoxin
    bio-equip.cn
    Smartox Biotechnology is specialized in supplying the life science research community with biological materials issued from animal's venoms. The company offers venom peptides for basic research and drug discovery solutions based on its venom collection and expertise.
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