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Apamin
Place of Origin:
France
Brand:
Smartox
Model:
0.5 mg
Supplier:
Smartox Biotech
Price:
75 €
Hits:
1525 
Updated:
6/18/2014
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    Apamin, Inhibitor of small conductance Ca2+-activated K+ channels Apamin is a neurotoxin that was originally isolated from Apis mellifera. Apamin binds to and inhibits the SK channels (small conductance Ca2+-activated K+ channels) in the brain and spinal cord. Apamin inhibits three subtypes of SK channels (KCa2.1, KCa2.2, and KCa2.3) with different affinity. Apamin does not affect KCa3.1 channel activity. Apamin most likely acts as a pore blocker such as Scyllatoxin or Tamapin, although residues both inside and outside of the pore region of the SK channels participate in apamin binding. The SK channels are present in a wide range of excitable and non-excitable cells, including cells in the central nervous system, intestinal myocytes, endothelial cells, and hepatocytes. Apamin technical information AA sequence: H-Cys1-Asn-Cys3-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys11-Ala-Arg-Arg-Cys15-Gln-Gln-His-NH2 Disulfide bonds: Cys1-Cys11 and Cys3-Cys15 Length (aa): 18 Formula: C79H131N31O24S4 Molecular Weight: 2027.34 Da Appearance: White lyophilized solid Solubility: water and saline buffer CAS number: [24345-16-2] Source: Synthetic Purity rate: > 98 % http://www.smartox-biotech.com/en/potassium-channel/132-apamin
    bio-equip.cn
    Smartox Biotechnology is specialized in supplying the life science research community with biological materials issued from animal's venoms. The company offers venom peptides for basic research and drug discovery solutions based on its venom collection and expertise.
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