Login    Join free Add to favorites    中文
Home >Products> Physiology | Pharmacology | Neurology >Electrophysiology> AmmTx-3
Physiology | Pharmacology | Neurology:  Electrophysiology   Microtome   Animal Experimental Equipment   Animal Cages  
AmmTx-3
Place of Origin:
France
Brand:
Smartox
Model:
0.1 mg
Supplier:
Smartox Biotech
Price:
180 €
Hits:
1732 
Updated:
6/18/2014
Related Products | Other Products | Related Suppliers
  • Product Detail
  • Company Profile
    AmmTx3, Blocker of A-type potassium channels AmmTx3 has been originally isolated from the venom of the scorpion Androctonus mauretanicus and is now offered by Smartox in its synthetic version. AmmTx3 binds on its target A-type potassium channel with an affinity of 66 pM in rat brain synaptosomes (Kv4 channels). As such, AmmTx3 should represent an excellent tool to study action potential firing frequency, spike initiation and waveform in excitable cells. AmmTx3 was indeed found to block A-type potassium currents from cerebellum granular cells and from striatum neurons but with IC50 values of 130 nM. AmmTx3 appears to be a pore blocker of Kv4.2 and Kv4.3 and seems to require the expression of the Kv4 associated protein DPP6. It should also contribute to our understanding of learning, memory and behavior. AmmTx3 shares very high sequence homology with two other A-type potassium channel blockers, Aa1 from Androctonus australis (94%) and BmTx3 from Buthus martensi (91%), and according to binding experiments the same channel target as well. AmmTx3 is a member of the a-KTX 15 family of toxins and consist of a single chain of 37 amino acid residues, with an N-terminal pyroglutamate, cross-linked by three disulfide bridges. AmmTx3 technical information AA sequence: Pyr-Ile-Glu-Thr-Asn-Lys-Lys-Cys8-Gln-Gly-Gly-Ser-Cys13-Ala-Ser-Val-Cys17-Arg-Lys-Val-Ile-Gly-Val-Ala-Ala-Gly-Lys-Cys28-Ile-Asn-Gly-Arg-Cys33-Val-Cys35-Tyr-Pro-OH Disulfide bonds: Cys8-Cys28, Cys13-Cys33 and Cys17-Cys35 Length (aa): 37 Formula: C158H263N51O47S6 Molecular Weight: 3821.52 Da Appearance: white lyophilized solid Solubility: water or saline buffer CAS number: Source: Synthetic Purity rate: > 98%
    bio-equip.cn
    Smartox Biotechnology is specialized in supplying the life science research community with biological materials issued from animal's venoms. The company offers venom peptides for basic research and drug discovery solutions based on its venom collection and expertise.
Request Information
Request Information: yes no
Request Quotation: yes no
refresh

I agree to share my inquiry with the other matching suppliers.

Send Now
Request Information

* Name:
Job Title:
* Tel:
Fax:
* E-mail:
Postcode:
Institution/Company:
Address:
* Country:
Request Information:
 yes no
Request Quotation:
 yes no
* Message:
* Verification Code:
 refresh
I agree to share my inquiry to the other matching suppliers.


Other Products

SiteMap
Copyright(C) 2006-2025 Bio-Equip E-mail:web@bio-equip.cn Tel:+86-17717806891 (Wechat)