PepSets peptide libraries are the rapid and cost effective solution for an immense range of bioactivity screening purposes.
Introduction to PepSets
Peptide libraries are a powerful tool in biological research for screening large numbers of peptides in the search for the few, critical bioactive peptides.
Mimotopes PepSets are custom-synthesized peptide libraries supplied unpuried for fast, efficient screening work. These sets of chemically synthesized individual peptides are made on a small scale using Mimotopes’ unique proprietary parallel array synthesis platform. PepSets comprising hundreds, or even thousands of peptides, are rapidly synthesized and shipped within a few weeks of ordering.
Initial screening can be done with peptides of sufficient purity for the purpose, rather than with highly puried peptides which are relatively expensive and slow to manufacture. In accord with this idea, Mimotopes’ peptide libraries are made on a small scale, subsequently progressing to larger quantities, or purifying the peptides, when it is known which peptides are going to be useful in detailed studies. This approach represents a huge time and cost saving for the user.
For users who require libraries of puried peptides, Mimotopes also offers a conventional puried custom peptide service.
How are PepSets Used
Peptide Libraries are used for diverse purposes, from peptide epitope mapping and structure-activity studies, to the search for peptide “drugs”.
PepSets are ideal for T cell epitope searching, because T cell epitopes are by nature short linear peptides from the primary protein sequence. They are also appropriate for scanning the primary sequence of proteins for linear, or “continuous”, antibody-dened epitopes. Where a bioactive sequence is already known, PepSets provide the ideal primary set of analogs for screening in structure-activity relationship (SAR) studies, also known as “Analoging”. To discover novel bioactive peptides, a PepSet consisting of many altered sequences, with natural or unnatural amino acid replacements, is synthesized and tested. This can result in the denition of highly promising candidate peptide therapeutics, or in the exclusion of classes of inactive peptide analogs from further study.
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Mimotopes Asia
Tel: +0086 13621502081
Fax: +0086 0510 83583038-2000
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