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Silica‑Based Chromatographic Stationary Phases
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- Silica‑Based Chromatographic Stationary Phases
COSTONES pre‑packed columns are developed based on high‑quality fully porous spherical silica, serving as general‑purpose liquid chromatography columns widely applied in reversed‑phase and normal‑phase chromatographic analyses. With rigorous manufacturing processes and state‑of‑the‑art chemical bonding technologies, this product series meets stringent requirements ranging from precise laboratory analysis to large‑scale preparative applications.
Core Technologies
- Ultra‑pure substrate: Adopts ultra‑pure silica with total metal ion content below 20 ppm, which effectively eliminates interferences from metallic impurities on polar compounds and reduces peak tailing.
- Superior physical structure: Features high specific surface area and outstanding mechanical strength to guarantee stable bed structure and separation performance even under prolonged high‑pressure operation.
- Unique bonding technology: Proprietary chemical bonding and modification processes endow the products with excellent chemical stability and batch‑to‑batch reproducibility.
Key Advantages
- Low silanol activity: Thorough end‑capping treatment effectively suppresses secondary retention effects and improves peak shapes for basic compounds.
- Uniform ligand bonding: Highly consistent surface modification of stationary phases ensures stable and durable separation selectivity.
- Ultra‑low metal content: Minimizes non‑specific interactions with analytes and improves analytical accuracy for complex samples.
- Narrow particle‑size distribution: Extremely narrow particle‑size distribution significantly enhances column efficiency while maintaining low system back‑pressure.
- Robust stability: Excellent acid‑alkali resistance and long service life greatly reduce per‑test cost.
Specification and Model
| Product | Particle size | Aperture | Specific surface area | Carbon content | pH |
| C18 | 5/10/20/30/50um | 120Å | 300m²/g | 16% | 2-8 |
| C8 | 5/10 um | 120Å | 300m²/g | 12% | 2-8 |
| Phenyl | 5/10 um | 120Å | 300m²/g | 8% | 2-8 |
| SiO₂ | 5/10/30/50 um | 120Å | 300m²/g | - | 2-8 |
| NH₂ | 5/10 um | 120Å | 300m²/g | 4% | 2-8 |
| CN | 5/10 um | 120Å | 300m²/g | 7% | 2-8 |
| Diol | 5/10 um | 120Å | 300m²/g | 8% | 2-8 |
Custom Products
COSTONES provides in‑depth customization services to help customers tackle challenging biochemical separation problems.
- Substrate customization: Ultra‑pure silica substrates with tailored pore size, specific surface area and mechanical strength can be manufactured for specific application requirements.
- Special bonded phases: Custom functional ligands and bonding processes are developed for highly challenging‑to‑separate compounds.
- Scalable supply: Supports linear scale‑up of stationary phases from microgram‑scale laboratory analysis to ton‑scale industrial production, enabling smooth process transfer.
Silica gel matrix chromatographic filler is the core stationary phase for HPLC analysis and preparation chromatography. It can bond C18, C8, phenyl, amino, diol and other functional groups, covering the fields of drugs, natural products, food, environment, chemical industry, life sciences, and taking into account the two major scenarios of analysis, detection and preparation.
1. pharmaceutical industry
Small molecule API and intermediates: API purity detection, impurity separation, preparation and chromatographic purification to obtain high-purity monomer and impurity reference substance; C18 silica gel packing is the mainstream.
Peptide drugs: 300 μ m large pore silica C18 filler, used for pilot and industrial refining of GLP ‑ 1, insulin, antimicrobial peptides and other peptides.
Antibiotics and fermentation products: separation of active components in fermentation broth, removal of fermentation by-products and degradation of impurities.
Pharmacopoeia quality detection: Determination of drug related substances and contents, used for QC laboratory analysis chromatographic column.
2. research and development of natural products and traditional Chinese Medicine
Isolation and purification of plant extract monomers: ginsenosides, flavonoids, alkaloids, terpenes, coumarins, Ginkgolides, paclitaxel, etc.
Fingerprint detection of traditional Chinese medicine, preparation of traditional Chinese medicine reference materials, for pharmacological research and new drug development; Bare silica gel C18、 Glycol based filler shall be used together.
3. food and cosmetics
Food testing: qualitative and quantitative analysis of food additives, pigments, preservatives, pesticide residues, mycotoxins, vitamins, polyphenols and anthocyanins.
Preparation of functional active substances: purification of antioxidant and whitening raw materials from plants; Separation and enrichment of functional components in food.
4. environmental testing
Detection of organic pollutants in water, soil and atmosphere: polycyclic aromatic hydrocarbons, phenols, herbicides, pesticide residues, endocrine disruptors.
Preparation and enrichment of environmental standards.
5. fine chemicals and new materials
Separation, purification and qualitative analysis of organic synthesis intermediates, chiral compounds, dyes, fragrances and unnatural amino acids.
Preparation of high purity chemical reference materials and reference materials.
6. life science and scientific research
Proteolytic peptides, oligosaccharides and metabolome samples (metabolites of biological fluid) were separated and analyzed.
Biomarkers in biological samples were screened and separated by mass spectrometry.
Welcome to inquire, pangjun@costones.com
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Suzhou COSTONES Instruments Co., Ltd. (COSTONES) is an instrument company focusing
on separation and purification. It is an equipment supplier and service provider
for biopharmaceutical, cell therapy and gene testing. It is committed to providing
users with industry-leading technical support and services.
The company has a perfect service system and executive power. It interprets the
user experience from the four aspects of technical communication, scheme design,
technical support and after-sales service, and tries to achieve seamless connection
in every link until it is recognized by customers.
For a long time, we have maintained good cooperative relations with domestic and
foreign suppliers. The main products include protein purification system,
compressible chromatographic column, ultrafiltration system, chromatographic
ultrafiltration accessories, etc., and provide maintenance services and customized
product services;
At present, Suzhou quarrying has provided high-quality services for
biopharmaceutical, cell therapy, research institutes and scientific research users.
It has carried out in-depth cooperation with customers and become a reliable partner
for customers to achieve win-win results.
We take quality first as the standard, quickly respond to customer needs, help
customers solve problems, improve efficiency, and take improving core
competitiveness for customers as our service tenet. We are willing to realize our
own value while creating value for customers and society through our unremitting
efforts.
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