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Liquid Chromatography Precolumn
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- Liquid Chromatography Precolumn
COSTONES liquid chromatography pre column is a liquid chromatography column developed based on high-quality ultra pure porous spherical silica gel, which is widely used in reversed-phase and normal phase chromatographic analysis. With the rigorous production process and cutting-edge chemical bonding technology, this series of products can meet all kinds of stringent requirements from laboratory precision analysis to large-scale preparation applications.
Technical core: high purity matrix: ultra pure silica gel with a total content of metal ions less than 20 ppm is used to effectively eliminate the interference of metal impurities on polar compounds.
excellent structure: it has high specific surface area and excellent mechanical strength to ensure stable column bed structure under long-term high-pressure operation.
unique bonding technology: the unique chemical bonding and modification process gives the product excellent chemical stability and reproducibility between batches.
Core advantages
Low silicon hydroxyl activity: after deep tail sealing treatment, it can effectively inhibit the secondary retention effect and improve the peak shape of basic compounds.
Uniform ligand bonding: the surface modification is highly consistent, ensuring the stability and durability of separation selectivity.
Ultra low metal content: reduce chelation, avoid tailing, and improve the analysis accuracy of sensitive compounds.
Narrow particle size distribution: the particle size distribution range is narrow, which significantly improves the column efficiency and reduces the system back pressure.
Excellent stability: it has excellent acid and alkali resistance stability and long service life, reducing the experimental operation cost.
Reversed phase/normal phase silica gel matrix chromatographic column
| Product | Particle size | Aperture | Specific surface area | Carbon content | pH |
| C18 | 3/5/10 um | 100Å | 300m²/g | 16% | 2-8 |
| C18H | 5/10 um | 120Å | 300m²/g | 18% | 2-8 |
| C18 AQ | 5/10 um | 100Å | 300m²/g | 13% | 2-8 |
| C8 | 3/5/10 um | 120Å | 300m²/g | 12% | 2-8 |
| C4-300 | 5/10 um | 300Å | 100m²/g | 3% | 2-8 |
| C8-300 | 5/10 um | 300Å | 100m²/g | 5% | 2-8 |
| C18-300 | 5/10 um | 300Å | 100m²/g | 8% | 2-8 |
| Phenyl | 3/5/10 um | 120Å | 300m²/g | 8% | 2-8 |
| SiO2 | 3/5/10 um | 120Å | 300m²/g | - | 2-8 |
| NH2 | 3/5/10 um | 120Å | 300m²/g | 4% | 2-8 |
| CN | 3/5/10 um | 120Å | 300m²/g | 7% | 2-8 |
| Diol | 5/10 um | 120Å | 300m²/g | 8% | 2-8 |
| Amide | 5/10 um | 120Å | 300m²/g | 4% | 2-8 |
Product item No：
Chromatographic Medium 10um
| 10um | 4.6250mm | 10250mm | 20250mm | 30250mm | 50250mm |
| C18 | 72110010004625 | 72110010010025 | 72110010020025 | 72110010030025 | 72110010050025 |
| C18H | 72210010004625 | 72210010010025 | 72210010020025 | 72210010030025 | 72210010050025 |
| C8 | 72510010004625 | 72510010010025 | 72510010020025 | 72510010030025 | 72510010050025 |
| C4-300 | 73010010004625 | 73010010010025 | 73010010020025 | 73010010030025 | 73010010050025 |
| C8-300 | 72910010004625 | 72910010010025 | 72910010020025 | 72910010030025 | 72910010050025 |
| C18-300 | 72810010004625 | 72810010010025 | 72810010020025 | 72810010030025 | 72810010050025 |
| SiO2 | 72010010004625 | 72010010010025 | 72010010020025 | 72010010030025 | 72010010050025 |
Chromatographic Medium 5um
| 5um | 4.6150mm | 4.6250mm | 10250mm | 20250mm | 30250mm |
| C18 | 72105010004615 | 72105010004625 | 72105010010025 | 72105010020025 | 72105010030025 |
| C18H | 72205010004615 | 72205010004625 | 72205010010025 | 72205010020025 | 72205010030025 |
| C18 AQ | 72305010004615 | 72305010004625 | 72305010010025 | 72305010020025 | 72305010030025 |
| C8 | 72505010004615 | 72505010004625 | 72505010010025 | 72505010020025 | 72505010030025 |
| C4300 | 73005010004615 | 73005010004625 | 73005010010025 | 73005010020025 | 73005010030025 |
| C8Bio | 72905010004615 | 72905010004625 | 72905010010025 | 72905010020025 | 72905010030025 |
| C18Bio | 72805010004615 | 72805010004625 | 72805010010025 | 72805010020025 | 72805010030025 |
| Phenyl | 70605010004615 | 70605010004625 | 70605010010025 | 70605010020025 | 70605010030025 |
| SiO2 | 72005010004615 | 72005010004625 | 72005010010025 | 72005010020025 | 72005010030025 |
| NH2 | 70505010004615 | 70505010004625 | 70505010010025 | 70505010020025 | 70505010030025 |
| CN | 70405010004615 | 70405010004625 | 70405010010025 | 70405010020025 | 70405010030025 |
| Phenyl | 70605010004615 | 70605010004625 | 70605010010025 | 70605010020025 | 70605010030025 |
| Diol | 70705010004615 | 70705010004625 | 70705010010025 | 70705010020025 | 70705010030025 |
| Amide | 70805010004615 | 70805010004625 | 70805010010025 | 70805010020025 | 70805010030025 |
Chromatographic Medium 3um
| 3um | 2.150mm | 2.1150mm | 4.650mm | 4.6150mm |
| C18 | 72103010002105 | 72103010002115 | 72103010004605 | 72103010004615 |
| Phenyl | 70603010002105 | 70603010002115 | 70603010004605 | 70603010004615 |
| SiO2 | 72003010002105 | 72003010002115 | 72003010004605 | 72003010004615 |
| NH2 | 70503010002105 | 70503010002115 | 70503010004605 | 70503010004615 |
| CN | 70403010002105 | 70403010002115 | 70403010004605 | 70403010004615 |
The preparation column is the core component of RP-HPLC preparation chromatography. Its core function is to enrich and purify hydrophobic/moderately hydrophobic organic compounds from gram to kilogram, and separate the crude products to high-purity monomers. It is widely used in the fields of new drug research and development, natural products, fine chemicals and so on.
1. Biopharmaceuticals
-Purification of peptide drugs: purification of GLP ‑ 1 (smegliptide, tilposide), insulin, antimicrobial peptides, growth peptides, and removal of impurities with similar structures such as missing peptides, oxidation, deamidation, etc; Large aperture C18 preparation column is specially suitable for purification of long-chain peptides, which is the mainstream scheme for industrialization of peptide bulk drugs.
-Chemical small molecule Bulk Drugs&pharmaceutical intermediates * *: purification of crude synthetic drugs, separation of related substances/impurity monomers, and acquisition of impurity reference materials; Support from laboratory semi preparation to pilot and production scale-up.
-Antibiotics and fermentation products: purification of fermentation products such as macrolides, vancomycin and bacitracin, and separation of fermentation by-products and degradation impurities.
-Oligonucleotides, protein fragments, biomarkers: preparation and separation of enzymatic protein peptides, oligosaccharides and other biomacromolecules (using 300 μ m large pore C18 packing).
2. development of natural products/traditional Chinese Medicine
-Isolation of highly active monomers from plant extracts: ginsenosides, paclitaxel, Ginkgolides, flavonoids, alkaloids, coumarins, terpenes, etc.
-Separation of traditional Chinese medicine extract and preparation of Monomer Standard for pharmacological research and new drug development. The structures of these substances are highly similar, and C18 preparation column is the preferred method to obtain high purity monomer.
3. chemistry and fine chemicals
-Purification of organic synthetic products, synthetic intermediates, unnatural amino acids, perfumes and dye monomers.
-Standard/reference preparation: preparation and enrichment of high-purity standard samples of agricultural and veterinary drugs, environmental pollutants and food additives.
4. food and cosmetics
-Purification of food functional components: anthocyanins, polyphenols, vitamin derivatives, functional oil monomers.
-Purification of cosmetic active substances: separation and purification of plant active extracts and whitening/antioxidant raw materials.
5. environmental and Life Sciences Research
-Preparation of high purity standards for environmental organic pollutants (polycyclic aromatic hydrocarbons, phenols).
-Separation and enrichment of metabolites and natural secondary metabolites at the scientific research level for mass spectrometry identification and pharmacological activity evaluation.
Welcome to inquire, pangjun@costones.com
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Suzhou COSTONES Instruments Co., Ltd. (COSTONES) is an instrument company focusing
on separation and purification. It is an equipment supplier and service provider
for biopharmaceutical, cell therapy and gene testing. It is committed to providing
users with industry-leading technical support and services.
The company has a perfect service system and executive power. It interprets the
user experience from the four aspects of technical communication, scheme design,
technical support and after-sales service, and tries to achieve seamless connection
in every link until it is recognized by customers.
For a long time, we have maintained good cooperative relations with domestic and
foreign suppliers. The main products include protein purification system,
compressible chromatographic column, ultrafiltration system, chromatographic
ultrafiltration accessories, etc., and provide maintenance services and customized
product services;
At present, Suzhou quarrying has provided high-quality services for
biopharmaceutical, cell therapy, research institutes and scientific research users.
It has carried out in-depth cooperation with customers and become a reliable partner
for customers to achieve win-win results.
We take quality first as the standard, quickly respond to customer needs, help
customers solve problems, improve efficiency, and take improving core
competitiveness for customers as our service tenet. We are willing to realize our
own value while creating value for customers and society through our unremitting
efforts.
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