PRDM1, also known as Blimp1, is a crucial transcriptional regulator that plays significant roles in various biological processes. It is a zinc finger protein with a complex structure containing multiple functional domains. In the immune system, PRDM1/Blimp1 is essential for the terminal differentiation of B cells into plasma cells, helping to suppress the expression of genes related to B cell proliferation and maintenance of the B cell phenotype, thereby facilitating the transition to plasma cells which are specialized for antibody production. Additionally, it also has important functions in other cell types and developmental contexts, such as influencing the differentiation of certain T cell subsets and participating in the regulation of some developmental processes in tissues like the skin. Its dysregulation has been implicated in various diseases, including certain types of cancers and autoimmune disorders, making it an interesting target for potential therapeutic interventions.
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