Promyelocytic leukemia protein (PML), also known as TRIM19, is a multifunctional protein belonging to the TRIM family and is best known for its role in the formation and stability of PML nuclear bodies (PML-NBs) within the cell nucleus. These nuclear bodies are membraneless organelles that serve as hubs for various cellular processes, including transcriptional regulation, DNA damage repair, apoptosis, and antiviral defense. PML itself is a 70 kDa protein with an N-terminal RBCC motif (RING, B-box, and coiled-coil domains) that facilitates its oligomerization and interaction with over 160 other proteins. The protein is also subject to post-translational modifications such as SUMOylation, phosphorylation, and ubiquitination, which regulate its function and localization. PML has been implicated as a tumor suppressor, with its downregulation observed in various cancers, highlighting its importance in maintaining cellular homeostasis and preventing carcinogenesis.
中文
