LDHA (Lactate Dehydrogenase A) is a key enzyme involved in glycolysis, catalyzing the conversion of pyruvate to lactate while regenerating NAD+ from NADH. This process is critical for maintaining cellular energy homeostasis, especially under anaerobic or hypoxic conditions. LDHA is highly expressed in various tissues and is a major component of the Warburg effect in cancer cells, promoting rapid glycolysis and lactate production to support tumor growth and survival. High levels of LDHA are associated with increased radiation resistance in tumors, making it a potential target for enhancing radiosensitivity. Additionally, LDHA expression is regulated by transcription factors such as c-MYC and SP1, which are modulated by proteins like TAB182, further influencing tumor metabolism and response to therapy.
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