Phospho-NF-κB p105 (Ser932) refers to the phosphorylated form of the NF-κB p105 protein at the serine residue 932. This post-translational modification is significant as it triggers a series of events that lead to the activation of the NF-κB signaling pathway, which is crucial in regulating immune and inflammatory responses. When p105 is phosphorylated at Ser932 by the IKK complex, it recruits the SCFβTrCP E3 ligase, leading to the ubiquitination and subsequent proteasomal degradation of p105. This degradation releases the active form of TPL-2, which in turn activates the MEK/ERK signaling pathway. Therefore, phosphorylation at Ser932 is a key regulatory step in controlling NF-κB activation and MAP kinase signaling, which coordinate the functions of lymphocytes and macrophages in the immune response.
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