Neuronally-derived Nitric Oxide Synthase (nNOS or NOS1) is a type of nitric oxide synthase enzyme. nNOS is mainly found in neurons and plays a crucial role in the central nervous system, particularly in synaptic signaling and plasticity. It is also present in skeletal muscle, where it regulates muscle contractility and local blood flow. nNOS interacts with a number of proteins, including post-synaptic density protein 95 (PSD-95), which is crucial for its localization at the postsynaptic density near the N-methyl-D-aspartate receptor (NMDAR). This interaction is important for coupling calcium influx through NMDA receptors to NO synthesis. nNOS has been implicated in various neuropathological states, including cognitive and motor deficits associated with early synaptic loss. It also negatively regulates neurogenesis under physiological and pathological conditions.
中文
