The 14-3-3 zeta protein, also known as YWHAZ, is a member of the 14-3-3 protein family, which consists of highly conserved acidic proteins with molecular weights ranging from 28 to 33 kDa. The 14-3-3 zeta protein plays a significant role in cells, participating in the regulation of many key cellular life activities, including metabolism, cell cycle, cell growth and development, cell survival and apoptosis, and gene transcription. Moreover, the 14-3-3 zeta protein is closely associated with the occurrence and development of various diseases, especially neurological disorders and cancers. In cancers, the expression level of 14-3-3 zeta protein is correlated with poor patient prognosis, including breast cancer, lung cancer, multiple myeloma, head and neck cancer, and glioblastoma, among others. The 14-3-3 zeta protein is also related to chemoresistance in tumors, with its overexpression increasing the resistance of tumor cells to chemotherapy drugs.
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