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B7-H6 Recombinant Rabbit mAb (S-1044-43)
B7-H6 Recombinant Rabbit mAb (S-1044-43)
Place of Origin:
Singapore
Brand:
Starter
Model:
S0B1084-25μl
Price:
100
Hits:
Updated:
8/27/2025
  • Product Detail
  • Company Profile

    Product Specification


    HostRabbit
    AntigenB7-H6
    SynonymsNatural cytotoxicity triggering receptor 3 ligand 1; B7 homolog 6 (B7-H6); NCR3LG1
    ImmunogenRecombinant Protein
    LocationCell membrane
    AccessionQ68D85
    Clone NumberS-1044-43
    Antibody TypeRecombinant mAb
    IsotypeIgG
    ApplicationWB
    ReactivityHu
    Positive SampleK562, HepG2, HEK-293
    Predicted ReactivityOr
    PurificationProtein A
    Concentration0.5 mg/ml
    ConjugationUnconjugated
    Physical AppearanceLiquid
    Storage BufferPBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
    Stability & Storage

    12 months from date of receipt / reconstitution, -20 °C as supplied

    Dilution


    applicationdilutionspecies
    WB1:1000Hu

    Background

    B7-H6 is a 51 kD type-1 transmembrane protein composed of 454 amino acids, with two immunoglobulin (Ig) domains, an IgC domain, an IgV domain, and a signal peptide. It interacts with NKp30, an activating receptor on natural killer (NK) cells, triggering innate immune responses. B7-H6 is primarily expressed in humans and rats as a surface protein. The surface form of B7-H6 binds to NKp30 expressed on NK cells and induces NK cell activation. In contrast, the soluble form of B7-H6, shed by metalloproteases ADAM-10 and ADAM-17, inhibits NK cell function by inhibiting NKp30 activation. Chronic stimulation of NK cells with the soluble form of B7-H6 can downregulate the cognate receptor of B7-H6, NKp30. B7-H6 expression has been associated with various cancers, including high-risk neuroblastoma, astrocytoma, and glioma. In high-risk neuroblastoma, serum concentrations of soluble B7-H6 are associated with downregulation of NKp30 expression, bone marrow metastasis, and chemoresistance. In astrocytoma, B7-H6 surface expression is associated with the WHO grade but not with survival rates. In glioma, B7-H6 expression is linked to disease progression and is significantly relevant to cancer progression and pathological type.

    bio-equip.cn
    AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
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