5-HT1A, also known as the serotonin 1A receptor, is a G protein-coupled receptor that plays a significant role in regulating a variety of physiological processes and has been implicated in several pathologies, particularly in the realm of mental health1. It is highly expressed in the brain, particularly in regions such as the hippocampus, septum, and prefrontal cortex, and is known to modulate serotonin activity, which in turn influences mood, anxiety, and other behaviors. The 5-HT1A receptor functions as both a presynaptic autoreceptor, inhibiting the release of serotonin, and as a postsynaptic heteroreceptor, modulating the effects of serotonin in the brain. It is also found on the cell bodies and dendrites of neurons, where it can influence neuronal excitability and synaptic transmission.
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