HuD, also known as ELAVL4, is an RNA-binding protein that is predominantly expressed in the brain and plays a crucial role in the development, maintenance, and functionality of the nervous system. It is involved in the regulation of gene expression at the post-transcriptional level and is known to interact with various types of RNAs, including mRNA, long non-coding RNA (lncRNA), and circular RNA (circRNA). HuD is implicated in several neurological disorders, including Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis (ALS). Its altered expression or activity is associated with disease pathology, suggesting that HuD's regulatory functions on target transcripts can have significant implications for disease progression. In terms of cellular function, HuD is involved in processes such as neuronal commitment, neurite outgrowth, and axonal recovery after injury. It achieves these functions by stabilizing target mRNAs, enhancing their translation, and regulating alternative splicing and polyadenylation of neuronal transcripts. HuD's function also extends to the regulation of the senescence-associated secretory phenotype (SASP) in cells. Downregulation of HuD can lead to increased levels of SASP factors, sensitizing cells to senescence inducers and promoting cellular senescence.
中文
