M6PR, or mannose 6-phosphate receptor, is a transmembrane glycoprotein that plays a critical role in cellular processes, particularly in the targeting of lysosomal enzymes. There are two types of M6PR: cation-dependent M6PR (CD-M6PR) and cation-independent M6PR (CI-M6PR). CI-M6PR is of particular interest due to its role in endocytosis and its potential as a therapeutic target. CI-M6PR is involved in the transport of newly synthesized lysosomal enzymes from the trans-Golgi network (TGN) to lysosomes, a process essential for cellular metabolism and catabolism homeostasis. It also mediates the endocytosis of extracellular ligands that bear M6P residues, such as insulin-like growth factor II (IGF-II) and retinoic acid, in addition to lysosomal enzymes. CI-M6PR's role extends beyond lysosomal enzyme targeting, as it has been implicated in cancer, immunology, and brain function. In cancer, CI-M6PR is overexpressed in several types of cancer cells, suggesting its potential as a target for cancer therapy. In the immune system, it plays a role in cell migration, wound healing, and viral infection.
中文
