PSEN1 Recombinant Rabbit mAb (S-1002-129),Starter_specification/price/image

Product Detail
Company Profile

Product Specification

Host	Rabbit
Antigen	PSEN1
Synonyms	Presenilin-1, PS-1, Protein S182, AD3, PS1, PSNL1
Immunogen	Synthetic Peptide
Location	Cell membrane, Endoplasmic reticulum membrane, Golgi apparatus membrane
Accession	P49768
Clone Number	S-1002-129
Antibody Type	Recombinant mAb
Isotype	IgG
Application	WB, IHC-P, ICC, ICFCM
Reactivity	Hu, Ms, Rt
Predicted Reactivity	Mq, Or
Purification	Protein A
Concentration	0.5 mg/ml
Conjugation	Unconjugated
Physical Appearance	Liquid
Storage Buffer	PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage	12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution

application	dilution	species
WB	1:1000
IHC-P	1:100
ICC	1:500
ICFCM	1:50

Background

PSEN1 is a protein involved in the gamma-secretase complex, which is crucial for the processing of several proteins, including the amyloid precursor protein (APP) and the Notch receptor. Mutations in the PSEN1 gene are associated with early-onset familial Alzheimer's disease (AD) and can lead to an increased production of amyloid-beta, the main component of amyloid plaques found in AD brains. Over 300 PSEN1 mutations have been discovered, some of which have been found in atypical AD or non-AD phenotypes such as frontotemporal dementia (FTD), Parkinson's disease (PD), dementia with Lewy bodies (DLB), or spastic paraparesis (SP).

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.