MCL1 (Myeloid Cell Leukemia 1) is a protein that belongs to the Bcl-2 (B-cell lymphoma 2) family of proteins. This family of proteins plays a vital role in regulating cell death, specifically apoptosis, a process that removes unwanted or damaged cells from the body. MCL1 expression is regulated by various signaling pathways and transcription factors. Its levels can be increased in response to growth factors and cytokines, promoting cell survival. Conversely, MCL1 levels can be decreased during stress conditions or by specific targeted therapies, leading to apoptosis. MCL1 is frequently overexpressed in various types of cancers, including leukemia, lymphoma, and solid tumors. Its anti-apoptotic function allows cancer cells to survive and proliferate despite damage or stress. As a result, MCL1 has been identified as a potential target for cancer therapy. Inhibiting MCL1 activity or reducing its expression can promote apoptosis in cancer cells, leading to tumor regression.
中文
