FN14 protein, also known as fibroblast growth factor-inducible 14 or TWEAK receptor, is an I-type transmembrane protein receptor that belongs to the tumor necrosis factor receptor superfamily. This protein has a molecular weight of approximately 14 kDa and is encoded by the FN14 gene, which is located on chromosome 16p13. FN14 protein plays a crucial role in various biological processes, including cell growth, survival, and apoptosis. One significant function of FN14 protein is its role in tumor development and progression. In particular, studies have shown that FN14 is overexpressed in certain types of cancer, including non-small cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC). In NSCLC, the overexpression of FN14 is associated with the activation of the epidermal growth factor receptor (EGFR), leading to tumor growth and metastasis. Similarly, in HCC, FN14 expression is linked to tumor progression and poor prognosis.
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