S-RMab® t-PA Recombinant Rabbit mAb (SDT-215-4),Starter_specification/price/image

Product Detail
Company Profile

Product Specification

Host	Rabbit
Antigen	t-PA
Synonyms	Tissue-type plasminogen activator, t-plasminogen activator, tPA
Immunogen	Recombinant Protein
Location	N/A
Accession	P00750
Clone Number	SDT-215-4
Antibody Type	Rabbit mAb
Application	Sandwich ELISA
Reactivity	Hu
Cross Reactivity	Does not recognize PAI-1, PIC complex, TAT complex
Purification	Protein A
Concentration	2 mg/ml
Purity	>95% by HPLC
Physical Appearance	Liquid
Storage Buffer	PBS, pH 7.4, 0.03% Proclin 300
Stability & Storage	12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

Background

Tissue plasminogen activator (abbreviated tPA or PLAT) is a protein involved in the breakdown of blood clots. It is a serine protease (EC 3.4.21.68) found on endothelial cells, the cells that line the blood vessels. As an enzyme, it catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for clot breakdown. Human tPA has a molecular weight of ~70 kDa in the single-chain form. tPA can be manufactured using recombinant biotechnology techniques; tPA produced by such means are referred to as recombinant tissue plasminogen activator (rtPA). Specific rtPAs include alteplase, reteplase, and tenecteplase. They are used in clinical medicine to treat embolic or thrombotic stroke. The use of this protein is contraindicated in hemorrhagic stroke and head trauma. The antidote for tPA in case of toxicity is aminocaproic acid. Increased levels of PAI-1 and tPA are associated with increased risk of cardiovascular disease, especially in patients with concomitant insulin resistance. It has been suggested that the tPA/PAI-1 complex would be an even stronger marker for thrombotic events than tPA antigen, and increased levels of tPA/PAI-1 complex were indeed recently shown to predict increased risk for first-ever stroke.

Recommend Antibody Pairs

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.