Home >Products> Reagents >Antibody> CD300LD Recombinant Rabbit mAb (S-1578-29)
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CD300LD Recombinant Rabbit mAb (S-1578-29)
CD300LD Recombinant Rabbit mAb (S-1578-29)
Place of Origin:
Singapore
Brand:
Starter
Model:
S0B1363-25μl
Price:
100
Hits:
Updated:
8/25/2025
  • Product Detail
  • Company Profile

    Product Specification


    HostRabbit
    AntigenCD300LD
    SynonymsCMRF35-like molecule 5; CLM-5; CD300 antigen-like family member D; CMRF35-A4; CD300d; CMRF35A4
    ImmunogenSynthetic Peptide
    LocationCell membrane
    AccessionQ6UXZ3
    Clone NumberS-1578-29
    Antibody TypeRecombinant mAb
    IsotypeIgG
    ApplicationWB
    ReactivityHu
    PurificationProtein A
    Concentration2 mg/ml
    ConjugationUnconjugated
    Physical AppearanceLiquid
    Storage Buffer

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

    Stability & Storage

    12 months from date of receipt / reconstitution, -20 °C as supplied

    Dilution


    applicationdilutionspecies
    WB1:1000Hu

    Background

    CD300LD is a member of the CD300 family of proteins and is a single transmembrane protein specifically highly expressed in neutrophils and polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs). It plays a significant role in tumor progression by regulating the recruitment of PMN-MDSCs and inhibiting T-cell infiltration through the STAT3-S100A8/A9 axis. Studies have shown that CD300LD knockout mice exhibit significantly inhibited tumor development, with reduced accumulation of PMN-MDSCs and increased numbers of immune effector cells such as CD4+ and CD8+ T cells and natural killer cells. This suggests that targeting CD300LD may remodel the tumor immune microenvironment from an immunosuppressive state to an activated state, offering potential for personalized targeted therapy. Additionally, CD300LD has been implicated in the regulation of interleukin-6 and tumor necrosis factor production, further highlighting its importance in immune responses.

    bio-equip.cn
    AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
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