OMNISEC REVEAL The ultimate in integrated advanced detection for GPC/SEC,Malvern Panalytical_specification/price/image

OMNISEC

The world’s most advanced multi-detector GPC/SEC system

Features and benefits

OMNISEC is a powerful tool for taking control of the performance, quality and value of your product, whether that’s a synthetic polymer in industry, a natural polymer or polysaccharide used in food or pharmaceutical products, or a protein or antibody used in biopharmaceuticals.

As a research tool, it accelerates research into these molecules by providing absolute information for a wide range of applications making it an ideal tool for universities. It reduces service expense and downtime and increases productivity with easy-to-use intuitive software.

The ultimate in advanced detection for GPC/SEC and UPLC/UHPLC
Fully integrated temperature controlled detector module for improved detector stability and sample characterization
More reliable measurements with market leading light scattering sensitivity
Measure low concentration samples with a highly sensitive and stable refractive index detector
Improved structural comparisons enabled with the unique mechanical auto balance of the differential viscometer
See the full range of your samples UV absorbance with the UV-PDA

Overview

OMNISEC REVEAL can be used to relate a polymer’s molecular properties to its bulk characteristics in a wide range of applications, from the packaging and paint industries to the manufacturing of food additives and pharmaceuticals. Its protein characterization capabilities can be used to study the effects of oligomerization, aggregation and conjugation on activity and efficacy in academic research and biopharmaceutical development.

The ultimate in advanced detection for GPC/SEC

Complete flexibility in detector configuration. Only purchase the detectors which add value to you now, with the security that any detector you require in the future can be installed onsite

Multi-detection SEC offers unparalleled information on the characterization of polymers, polysaccharides and proteins

Measuring absolute molecular weight, intrinsic viscosity, hydrodynamic radius, Mark-Houwink parameters, radius of gyration, composition, conformation and more
Rely on OMNISEC to help you understand, control and optimize your product performance
Detection and quantification of protein aggregation to drive faster sample characterization and development

Fully integrated temperature-controlled detector module for improved detector stability and sample characterization

Improve separations and result accuracy with the column oven and temperature-controlled integrated detector compartment – all installed as standard!
Minimized inter-detector tubing, maintained at the same temperature as the detector, reduces band broadening effects to further increase signal quality

More reliable measurements with market leading light scattering sensitivity

Measure low concentration samples with a highly sensitive and stable refractive index detector

Measure molecular weight of polymers as low as 200 g/mol!
Injection masses as low as 100 ng for characterization of samples which were previously unmeasurable using advanced detection
Make sure you don’t miss low molecular weight and low concentration contaminants or protein fragments

Improved structural comparisons enabled with the unique mechanical auto balance of the differential viscometer

Boost lab productivity and reduce service costs with a novel self-balancing viscometer design with user exchangeable capillaries

See the full range of your samples UV absorbance with the UV-PDA

Distinguish chemical changes by measuring absorbance across the full UV/Vis spectrum (190-900nm) using the photodiode array
All UV channels are recorded giving you the flexibility to choose what wavelength to use in post-processing

All systems can be fully serviced and supported onsite

No need to worry about shipping systems for service or support, all units can be fully serviced onsite to ensure minimum downtime

How it works

Following separation of the sample according to its hydrodynamic volume the sample will pass through 1 or more detectors where its presence is recorded. OMNISEC REVEAL is a fully integrated multi-detection module which can contain up to 4 different detectors.

The RI and UV detectors give information about the concentration of the components in the sample. The light scattering detectors respond to the intensity of light scattered by the sample which is related to molecular weight and also allows Rg of large molecules to be calculated. The viscometer measures the changing solution viscosity to calculate the intrinsic viscosity of the sample which is a measure of structure.

Coupling the efficient sample separation of OMNISEC RESOLVE with the fully optimized, multi-detector, information-rich analysis delivered by OMNISEC REVEAL, Malvern Panalytical has produced a market-leading solution for researchers and formulators developing novel natural and synthetic polymers, pharmaceutical and biopharmaceutical products and foods.

	Refractive Index Measure the concentration of any solute with excellent sensitivity
	UV/Vis PDA Measure absorbance at any wavelength from 190-900 nm Assess changes in absorbance spectra Characterize copolymers
	Light Scattering Measure absolute molecular weight in a wider range of applications Measure as little as 100 ng of material Measure molecular weights down to 200 Da
	Viscometer Better intrinsic viscosity measurements thanks to automated balancing Reduced service cost and time thanks to user-exchangeable capillaries

Dimensions (W, D, H)	420, 640, 600 mm
Weight	40 kg
Detector temperature range	20 - 65 °C
Software	OMNISEC software v10 (or later)
Data acquisition rate	100 Hz
Patents	US20140060162A1 & EP2619543B1 "Modular capillary bridge viscometer" US20140144214A1 & EP2619544A1 "Automatically balanced capillary bridge viscometer"

Detector	Light scattering
Measurement principle	RALS 90° angle, LALS 7° angle
Light source	50 mW, 640 nm laser
Cell volume	18 µL
Dynamic range	2500 mV
Baseline noise	<0.1 mV
Baseline drift	<0.2 mV/hr

Detector	Differential refractive index
Measurement principle	Deflection
Cell volume	12 µL
Dynamic range	±2.5 x 10^-4 RIU
Baseline noise	<10^-7 RIU
Baseline drift	<3 x 10^-7 RIU/hr

Detector	Viscometer
Measurement principle	4-capillary Wheatstone bridge with self-balancing mechanism and user-exchangeable capillaries
Detector volume	17 µL/capillary
Differential pressure dynamic range	±2500 Pa
Differential pressure baseline noise	0.3 Pa
Inlet pressure dynamic range	100 kPa
Inlet pressure baseline noise	0.01 kPa
Baseline drift	<0.2 kPa/hr

Detector	Diode-array-based UV/Vis spectrometer
Wavelength	190 - 900 nm
Number of wavelengths	1024
Wavelength accuracy	<1 nm
Wavelength resolution	0.6 nm
Cell volume	7.5 µL
Path length	10 mm
Baseline noise	2 x 10^-5 AU
Baseline drift	5 x 10^-4 AU/hr

Measurement type	Absolute molecular weight
Measurement range	200 - >10⁷ g/mol
Minimum quantifiable mass	Using HPLC-SEC: 100 ng of 100 kDa molecular weight polystyrene in THF 100 ng of BSA in PBS
Measurement principle	Light scattering (LALS or RALS)

Measurement type	Intrinsic viscosity
Minimum quantifiable mass	1 µg of 100 kDa molecular weight polystyrene in THF
Measurement principle	4-capillary Wheatstone bridge

Measurement type	Concentration
Minimum quantifiable mass	Using HPLC-SEC: 100 ng of 100 kDa molecular weight polystyrene in THF 100 ng of BSA in PBS
Measurement principle	Differential refractive index detection

Temperature	15 °C - 30 °C