| Cell Line Description |
The H22 cell line is a murine hepatocellular carcinoma cell line derived from liver tumor cells. H22 cells exhibit typical characteristics of hepatocellular carcinoma, including rapid proliferation, resistance to apoptosis, and the ability to form tumors when injected into appropriate animal models. Because these cells are derived from a mouse model, they are particularly suitable for studying the interaction between cancer cells and the immune system in a controlled environment. Researchers have utilized H22 cells to evaluate the efficacy of various immunotherapeutic agents, including checkpoint inhibitors and cancer vaccines. H22 cells are also used to study the role of liver-specific metabolic pathways and genetic mutations in the progression of hepatocellular carcinoma. In addition, the H22 cell line can be used to create the CDX (cell line derived xenograft) H22 xenograft mouse model. Studies have shown that the orthotopic H22 model increases immune cell populations of regulatory T cells and myeloid-derived suppressor cells in the bone marrow, spleen, and tumor tissue. |
中文
