| Cell Line Description |
HGC-27 cells are derived from human gastric adenocarcinoma, derived from metastatic lymph nodes of patients diagnosed with undifferentiated carcinoma. These cells exhibit polygonal or short spindle morphology and form a monolayer when adhered to glass surfaces, retaining the undifferentiated features of the original tumor. Enzyme activity in HGC-27 cells is generally low or negative, with the exception of ATPase, lactate dehydrogenase, and leucine aminopeptidase. Studies using HGC-27 have provided insights into cellular processes such as epithelial-mesenchymal transition (EMT), a key event in cancer metastasis. In addition, this cell line has been used to explore receptor signaling pathways and their effects on cancer cell behavior, providing key data for the development of targeted therapies. |
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