| Cell Line Description |
3D4/21 is an alveolar cell line isolated from 27-day-old pig lungs in 1998. The 3D4/21 cell line is derived from a single-cell clone of the parent (continuous porcine alveolar macrophage cell line). This cell is an effective tool for studying the immune characteristics and viral infection mechanisms of pigs. There are 844 InDels greater than 1 kb in the 3D4/21 cell genome, of which 12 regions are deletions greater than 100 kb. In addition, compared with primary porcine alveolar macrophages, 82 genes (including CD163) were transcribed missing in 3D4/21 cells, and 72 genes were transcribed. Further combined with Hi-C structure, it was found that the topologically associated domain (TAD) fusion caused by the deletion may lead to abnormal gene function. |
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