The vector of anti-TEM8 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human TEM8. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-TEM8 antibody linked to CD3-zeta and CD137 (4-1BB) signaling domains. And the vector product was designed for cell therapy that targets tumor vasculature, including the tumor vascular bed, for example, glioma and breast cancer.
https://www.creative-biolabs.com/car-t/pcdcar1-tem8-h-bb%CE%B6-t-559.htm |
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