The vector of anti-TEM8 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human TEM8. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-TEM8 antibody linked to FcεRIγ signaling domains. And the vector product was designed for cell therapy that targets tumor vasculature, including the tumor vascular bed, for example, glioma and breast cancer.
https://www.creative-biolabs.com/car-t/pcdcar1-tem8-h-fc%CE%B5ri%CE%B3-t-552.htm |
中文
