For the last few decades scientist have been researching the involvement of the immune system in cancer development to discover potential cure. Immune cells has been known to play an important role in regulating tumor progression, thus stimulating immune reactions towards tumors can be an attractive therapeutic targeting cancer. More and more clinical data has been shown positive signs of immunotherapy and cell therapy as potential cure for cancer.
Recent studies have illustrate how cancer cells circumvents the immune system through overexpression of PD-L1, which binds to and activates the PD-1 protein on the T cell leading to immune tolerance. Thus PD-1/PD-L1 inhibitors pharmacologically preventing the PD-1/PD-L1 interaction may provide a potential way to facilitate immune response to kill the tumor. There are quite PD-1 inhibitors in clinical trials as well as available in the market approved by FDA.
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