Cell penetrating peptides (CPPs), also known as protein transduction domains (PTDs) or membrane transduction peptides (MTPs), are small molecular peptides that consist of 5-30 amino acid residues, which not only penetrate the cell membrane by themselves, but also carry a variety of exogenous substances such as peptides, proteins, nucleic acids and nanoparticles in a covalent or non-covalent binding manner into cells. CPPs have a wide range of transmembrane targets and can enter a variety of cell types, even through the blood-brain barrier when applied in vivo.
As an effective bioactive molecular intracellular transport tool, CPPs have broad application prospects in cell biology and cellular immunology, especially in the fields of drug development, gene biotherapy and tumor targeted therapy.
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