Rat Oxidized lowdensity lipoprotein antibody (OLAb) ELISA Kit,Abbkine_specification/price/image

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Hypercholesterolemia is closely associated with increased risk of atherosclerosis. The cholesterol accumulated in the atherosclerotic plaque is derived primarily from low-density lipoprotein (LDL). Oxidation of LDL is now accepted as a critical event in the atherogenic process. Free radicals like superoxide and nitric oxide (-O2 , NO) generated in biological reactions in the body contribute to the oxidation of LDL. The NO radical has been shown to oxidize apolipoprotein B a constituant of LDL. Similarly, lipoxygenases and oxidants like peroxynitrite can oxidize the lipid moieties in LDL. It has been demonstrated that oxLDL and not native LDL is taken up by scavenger receptors on monocytes, smooth muscle cells and macrophages in the blood vessels. The oxidation of LDL increases the affinity of oxLDL to acetyl receptors of macrophages. As this pathway of oxLDL uptake is unregulated, it results in the formation of lipid-laden macrophages (foam cells).

Rat Oxidized lowdensity lipoprotein antibody (OLAb) ELISA Kit employs the competitive enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with an antibody specific to OLAb. Standards or samples are then added to the appropriate microtiter plate wells with a Horseradish Peroxidase (HRP)-conjugated OLAb and incubated. The competitive inhibition reaction is launched between with HRP labeled OLAb and unlabeled OLAb with the antibody. A substrate solution is added to the wells and the color develops in opposite to the amount of OLAb in the sample. The color development is stopped and the intensity of the color is measured.

Rat Oxidized lowdensity lipoprotein antibody (OLAb) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Find more details at http://www.abbkine.com/product/rat-oxidized-lowdensity-lipoprotein-antibody-olab-elisa-kit-kte100954/

Abbkine Scientific Co., Ltd. was founded by a number of scientists and marketing experts in the field of life science in California in 2012. With growing demands from Asia Pacific, it move its headquarters to China. Combining cutting edge technology from United States with China's manufacturing engineering and cost advantages, we aim to provide innovative, high quality assay kits, recombinant proteins, antibodies and other research tools to accelerate life science fundamental research, drug discovery, etc.