Anti-sperm antibodies are produced by cells of the adaptive immune system and are the cause of approximately 7% of male infertility incidences. They can bind to sperm, inhibiting their movement, stopping recognition and entry into the egg, or targeting sperm for destruction when they reach the female reproductive tract.Over half of men who have undergone a vasectomy develop anti-sperm antibodies.Antisperm antibodies in the form of autoantibodies in male and alloantibodies in female patients directed against sperm antigens may prevent fertilization of the oocyte into the female genital tract and are therefore one of the major reasons for an immunologically induced infertility. Fertility disorders of unknown etiology of male as well as female patients result to a considerably amount (up to 20%) from antisperm antibodies.
Rat Anti-sperm antibody IgG (AsAb-IgG) ELISA Kit employs the competitive enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with an antibody specific to AsAb-IgG. Standards or samples are then added to the appropriate microtiter plate wells with a Horseradish Peroxidase (HRP)-conjugated AsAb-IgG and incubated. The competitive inhibition reaction is launched between with HRP labeled AsAb-IgG and unlabeled AsAb-IgG with the antibody. A substrate solution is added to the wells and the color develops in opposite to the amount of AsAb-IgG in the sample. The color development is stopped and the intensity of the color is measured.
Rat Anti-sperm antibody IgG (AsAb-IgG) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
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