C-X-C chemokine receptor type 7 is a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP) and was considered to be an orphan receptor, it has been later been shown to bind the chemokines CXCL12/SDF-1 and CXCL11.The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. Whereas some reports claim that the receptor induces signaling following ligand binding, recent findings in zebrafish suggest that CXCR7 functions primarily by sequestering the chemokine CXCL12.
Human CXC-chemokine receptor 7 (CXCR7) ELISA Kit employs a two-site sandwich ELISA to quantitate CXCR7 in samples. An antibody specific for CXCR7 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyCXCR7 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for CXCR7 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of CXCR7 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Human CXC-chemokine receptor 7 (CXCR7) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Find more details at http://www.abbkine.com/product/human-cxc-chemokine-receptor-7-cxcr7-elisa-kit-kte62268/
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