EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform.Tumor necrosis factor receptor superfamily member 27 is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Multiple alternatively spliced transcript variants have been found for this gene, but some variants lack sufficient support.
Human Tumor necrosis factor receptor superfamily member 27 (EDA2R) ELISA Kit employs a two-site sandwich ELISA to quantitate EDA2R in samples. An antibody specific for EDA2R has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyEDA2R present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for EDA2R is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of EDA2R bound in the initial step. The color development is stopped and the intensity of the color is measured.
Human Tumor necrosis factor receptor superfamily member 27 (EDA2R) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
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