Probable N-acetyltransferase 8B encoded by NAT8B is highly similar to the N-acetyltransferase 8 (NAT8) gene product, which is a kidney and liver protein with homology to bacterial acetyltransferases involved in drug resistance. NAT8B is localized on chromosome 2 in the vicinity of the NAT8 gene and may represent a pseudogene of NAT8. NAT8B contains two polymorphic nonsense mutations that disrupt the active site of the protein. The full-length product of NAT8B contains a complete acetyltransferase domain and is identical in length to NAT8.
Human Probable N-acetyltransferase 8B (NAT8B) ELISA Kit employs a two-site sandwich ELISA to quantitate NAT8B in samples. An antibody specific for NAT8B has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyNAT8B present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for NAT8B is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of NAT8B bound in the initial step. The color development is stopped and the intensity of the color is measured.
Human Probable N-acetyltransferase 8B (NAT8B) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
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